Areas covered by AGEING :
• Skin structure and aging
• Cellulite development
• Vascular tone & water retention
Skin health, blood & lymph circulation and conditions such as cellulite are interlinked at several levels. They involve complex processes that include microcirculation, local fat accumulation, hormonal factors, altered matrix metabolism, oxidative stress, inflammatory changes, and alterations in lymphatic drainage.
The AGEING panel provides information about the potential effect of your individual genetic variation on your overall esthetic health and well-being. Since we focus especially on research regarding gene x environment interactions the genetic information leads to specific personal modifications to your diet and lifestyle which can help with healthy skin aging and prevent or combat processes such as cellulite, water retention, etc
We also all have common genetic variants that affect processes important to our skin health; however because genes do not act alone, by making suitable changes in DIET, LIFESTYLE etc. we can exert some control over our apparent genetic destiny – with simple adjustments to our lives we can make significant improvements in our long term skin health, and even reduce / reverse effects of aging that have already appeared.
The genetic variations are described below:
PROCESS |
GENE |
VARIANT TESTED |
SKIN STRUCTURE |
MMP1 MMP3 COL1A1 |
G-1607>GG 5A/6A Sp1 G>T |
OXYDATIVE STRESS AND INFLAMMATION |
SOD2 CAT GPX1 EPHX GSTM1 GSTT1 IL6 TNE |
C-28T -262 C>T Pro198Leu (C<T) Glu298Asp (G89) G-308A Thr241Met (C>T) G-174C G-308A |
HYPERTENSION AND VASCULAR TONE |
ACE AGT NOS3 BRKRB2 |
ID Met235Thr G894T +9/-9 INDEL |
CARBOHYDRATE SENSITIVITY & GLYCATION |
ACE PPARG TCF7L2 ADRB2 FTO FABP2 |
ID ProAla (12) C/T Arg16gly A/T Ala54Thr |