Metabolic, Cardiologic, Lipemic, Fertility, Hormonal and Infectious (included Antibodies against Covid-19) assessments
Heavy metals, metabolic and infectious assessments
The intestinal check of the gastrointestinal Microbiome (on a stool sample)
GENETICS (NUTRIGENETICS - WHOLE GENOME)
Nutrigenetics is a science that studies the effect of genetic variations on the interaction between diet and health
Nutrigenetics is the retrospective analysis of genetic variations among individuals with respect to the interaction between diet and disease. It is an applied science that studies how the genetic makeup of an individual affects the response to diet and the susceptibility to diet-related diseases.
This necessitates the identification of gene variants associated with differential responses to nutrients and with higher susceptibility to diet-related diseases. The ultimate goal of nutrigenetics is to provide nutritional recommendations for individuals in what is known as personalized or individualized nutrition.
Due to evolutionary processes, humans differ in their DNA, more precisely in so-called SNPs (short for “single nucleotide polymorphism”).Among others, SNPs influence the way individuals absorb and process food components. Physiological activity in the human organism that concerns the consumption or transportation of nutrients is also connected with the reciprocation of various genetic variants. This assumption forms the basis for nutrigenetic sciences.Moreover, different nutrigenetic processes in the human body can imply an advantage in terms of natural selection. Thus, for example, evolution urged people to digest lactose from cow milk.
Another example, some variants of the APOA5 gene make their carriers susceptible to high blood triglycerides, a risk factor for cardiovascular disease. Low calorie and omega-3 rich diets can help prevent disease development. About 30% of Asians and Hispanics carry APOA5 risk variants.
A single-nucleotide polymorphism (SNP, pronounced snip) is a DNA sequence variation occurring when a single nucleotide adenine (A), thymine (T), cytosine (C), or guanine (G]) in the genome (or other shared sequence) differs between members of a species or paired chromosomes in an individual.
For example, two sequenced DNA fragments from different individuals, AAGCCTA to AAGCTTA, contain a difference in a single nucleotide.
Within a population, SNPs can be assigned a minor allele frequency — the lowest allele frequency at a locus that is observed in a particular population. This is simply the lesser of the two allele frequencies for single-nucleotide polymorphisms. There are variations between human populations, so a SNP allele that is common in one geographical or ethnic group may be much rarer in another.
Variations in the DNA sequences of humans can affect how humans develop diseases and respond to pathogens, chemicals, medication, vaccines, and other agents.
SNPs are also thought to be key enablers in realizing the concept of personalized medicine. However, their greatest importance in biomedical research is for comparing regions of the genome between cohorts (such as matched cohorts with and without a disease).
Moreover, the genetic profile allows to identify the most appropriate type of physical activity for each individual.
In the long run, nutrigenetics should allow nutritionists and physicians to individualize health and diet recommendations. Consequently, preventive medicine, diagnostics and therapies could be optimized.
Nutrigenomics (not to be confused with Nutrigenetics)is a branch of nutritional genomics and is the study of the effects of foods and food constituents on gene expression. This means that nutrigenomics is research focusing on identifying and understanding molecular-level interaction between nutrients and other dietary bioactives with the genome.
Nutrigenomics has also been described by the influence of genetic variation on nutrition, by correlating gene expression or SNPs with a nutrient's absorption, metabolism, elimination or biological effects. By doing so, nutrigenomics aims to develop rational means to optimise nutrition with respect to the subject's genotype.
Our genes interact with our environment - they can be influenced and regulate it at the same time - there is a bilateral relationship GENE-ENVIRONMENT.
This tool is going to change the way we exercise the medicine in all its fields. The knowledge of the predisposition to suer from diseases, not only hereditary but alsocommon diseases, will allow to customize the programs of preventive medicine depending on the particular risk of suering an illness, just as it will allow the prescription of suitablemedication to the specic person, in at the precise dose. This is what we call Precision Medicine exercised in multidisciplinary centers where Genomic Medicine is included.Technology and articial intelligence applied to INTERPRETATION of variants in the genome, the integration of logistics and services, together with the genetic counseling are the key to the value of INTEGRAL SERVICE OF WHOLE GENOME SEQUENCING (WGS).
WHAT THE TEST SCREENS FOR
It gives insights on many hereditary diseases including those in the following categories:
Endocrine and Metabolic Disorders
Insights on how effectively your patient metabolize or potentially react to 150+ drugs that treat a variety of conditions, including those in the following categories:
Cardiovascular Endocrinology Gastroenterology
Hematology Infectious Diseases Neurology
Oncology Pain Medicine Psychiatry
Physical Appearance Sensory Perception Substance Reaction
Insights on more than 50 traits related to:
Athleticism Behavior Cardiovascular Hormones
Immune System Longevity Metabolism Nutrition and Diet
Insights on Ancestry
This test is a rapidly-evolving field primarily providing evidence-based predictions of how the tested individual’s genetic profile may affect reaction to certain drugs.
Factors such as drug-drug interaction and also age, diet, ethnicity, family and personal health history, can also impact the likelihood of exhibiting certain drug reactions, independently of genotype-based predictions.
Based on the results, patients would be able to make changes to medical care- including, but not limited to, changes in dosage or frequency of medication, diet and/or exercise regimens, or pregnancy planning - but not without the prior advice of and consultation with a healthcare professional.
The intestinal check of the gastrointestinal Microbiome (on a stool sample)
- The intestinal flora: Bacteroidetes & Firmicutes.
They are anaerobic bacteria involved in the digestive process.
- Lactic acid bacteria and the pH value
The colon environment should be slightly acidic for an optimal fermentation process. Ideal pH values are between 6 and 7.
- Diversity, enterotype and dysbiosis
The intestinal flora is based on the principle that "the more types of bacteria, the better". These should come from the large families Bacteroidetes andFirmicutes as well as the Actinobacteria. To monitor this diversity, the Shannon index and the Firmicutes to Bacteroidetes ratio have prevailed. These two indices provide a good overview of the health status of the intestinal flora. Dysbiosis is also described as the loss of obligate anaerobic bacteria (e.g. Bacteroides, Ruminococcus) in favour of facultatively anaerobic bacteria, especiallyproteobacteria. The cells experience oxidative stress and thus intestinal inflammation is favoured. Without a healthy amount of bacteria in the area of the mucus barrier, the immune system will also suffer.
- Intestinal microbiome and chronic diseases
Studies on the mouse model and with patient cohorts have shown that in overweight and diabetes mellitus type 2, in particular bacterial species of Bacteroidetes are lost.
A low bacterial diversity was clearly associated with overweight, low grade inflammation and metabolic derailment.
Conversely, the results also indicate that a (very) diverse intestinal flora can be regarded as an indicator of metabolic homeostasis and possibly even as a protective factor against metabolic derailment.
Inflammatory intestinal diseases (IBD) are also associated with intestinal microbiome dysbiosis.
Increased zonulin levels may correlate with a disturbed intestinal barrier and increased intestinal permeability (leaky gut), the calprotectin indicates inflammatory processes , the pancreatic elastase is decreased in the case of pancreatic insufficiency.
For a complete indoor check-up, as experts:
1- WATER QUALITY (CHLORINE, NITRITE, NITRATE)
2- AIR QUALITY (TOLUENE, ALCOHOL, AMMONIA, ETHANOL)
4 - FORMALDEHYDE
5 - WIFI
6 - ELECTROMAGNETIC FIELDS
7 - IONIZING RADIATION
8 - NOISE POLLUTION
9 - DUST
10 - METHANE
11 - HUMIDITY
12 - TEMPERATURE
13 - VOC
14 - CO
15 - CO2
You can choose to perform a complete check-up with the measurement of all these parameters or to test the single parameter you need.
The check-up will consist in a visit of the building (apartment, house or working place) by our expert architect who will submit a questionnaire, identify the thermal bridges, as well as any other possible cause of indoor pollution (cleaning products, household products, cosmetics, molds, furniture, paints, etc etc ...).
The specialist will then provide you with a report with possible problems and solutions.
This service is innovative and allows to detect pollutants inside the house, pollutants that can be the cause of many diseases (respiratory, dermatological, metabolic, cardiovascular, etc ..).
For scheduling an appointment for your indoor check-up: tel. +41 78 218 74 64
Chemin des Mouilles 4
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